ATP11C
| ATP11C | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pengidentifikasi | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Alias | ATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL | ||||||||||||||||||||||||||||||||||||||||||||||||||
| ID Eksternal | OMIM: 300516; MGI: 1859661; HomoloGene: 27862; GeneCards: ATP11C; OMA:ATP11C - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Nomor EC | 7.6.2.1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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ATP11C adalah enzim yang pada manusia disandikan oleh gen ATP11C.
Fungsi
ATP11C menyandikan anggota keluarga ATPase tipe-P Tipe IV yang diperkirakan mentranspor atau 'membalik' aminofosfolipid. Protein terkait pada mencit sangat penting untuk perkembangan sel B dan sel darah merah,[3][4] serta untuk pencegahan kolestasis intrahepatik.[5]
Referensi
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.
- ^ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.
- ^ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.
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