Allopregnanolon

Allopregnanolon
Nama
Nama IUPAC
1-(3-Hidroksi-10,13-dimetil-
2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradekahidro-
1H-Siklopenta[a]
fenantren-17-yl)etanon
Nama lain
3α,5α-Tetrahidroprogesteron
Penanda
Model 3D (JSmol)
ChemSpider
Nomor EC
Nomor RTECS {{{value}}}
  • InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14?,15-,16+,17-,18+,19+,20+,21-/m1/s1
    Key: AURFZBICLPNKBZ-JMTGGFPBBC
  • CC(=O)[C@H]2CC[C@H]1[C@@H]3CCC4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C
Sifat
C21H34O2
Massa molar 318,49 g/mol
Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa).
Referensi

Allopregnanolon (bahasa Inggris: Allopregnanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone, THP, ALLO) merupakan neurosteroid yang mengikat pencerap GABA. ALLO disintesis di dalam otak oleh neuron piramidal[1] dari progesteron dengan bantuan enzim 5alfa-reduktase tipe I dan 3alfa-hidroksisteroid dehidrogenase.[2]

Rujukan

  1. ^ (Inggris) "Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice". Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago; Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A. Diakses tanggal 2010-06-18.
  2. ^ (Inggris) "Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis". Department of Psychiatry, Psychiatric Institute, University of Illinois; Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. Diakses tanggal 2010-06-18.


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