CYP1B1

CYP1B1
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	3PM0
Pengidentifikasi
Alias	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1, cytochrome P450 family 1 subfamily B member 1, ASGD6
ID Eksternal	OMIM: 601771; MGI: 88590; HomoloGene: 68035; GeneCards: CYP1B1; OMA:CYP1B1 - orthologs
Nomor EC	4.2.1.152 1.14.14.1, 4.2.1.152
Pola ekspresi RNA
	Ekspresi tertinggi di
	Perikardium; ; cartilage tissue; ; synovial joint; ; trigeminal ganglion; ; spinal ganglia; ; Membran sinovial; ; tendon of biceps brachii; ; superficial temporal artery; ; Folikel rambut; ; Uretra;
	Ekspresi tertinggi di
	stroma of bone marrow; ; vestibular membrane of cochlear duct; ; renal corpuscle; ; cumulus cell; ; Badan siliaris; ; lactiferous gland; ; mesenteric lymph nodes; ; Vas deferens; ; ankle joint; ; tunica media of zone of aorta;
	Referensi data ekspresi selengkapnya
	; ; ; ;
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	iron ion binding; oxygen binding; metal ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; aromatase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; monooxygenase activity;
Komponen seluler	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membran; Retikulum endoplasma; mitokondria;
Proses biologis	toxin metabolic process; steroid metabolic process; retina vasculature development in camera-type eye; cellular response to organic cyclic compound; epoxygenase P450 pathway; endothelial cell-cell adhesion; omega-hydroxylase P450 pathway; Angiogenesis; cellular aromatic compound metabolic process; sterol metabolic process; response to toxic substance; penglihatan; blood vessel morphogenesis; trabecular meshwork development; negative regulation of NF-kappaB transcription factor activity; regulation of reactive oxygen species metabolic process; retinal metabolic process; endothelial cell migration; nitric oxide biosynthetic process; retinol metabolic process; Adhesi sel; negative regulation of cell population proliferation; positive regulation of apoptotic process; positive regulation of receptor signaling pathway via JAK-STAT; negative regulation of cell adhesion mediated by integrin; xenobiotic metabolic process; cellular response to hydrogen peroxide; membrane lipid catabolic process; retinal blood vessel morphogenesis; positive regulation of angiogenesis; positive regulation of vascular endothelial growth factor production; intrinsic apoptotic signaling pathway in response to oxidative stress; arachidonic acid metabolic process; negative regulation of cell migration; estrogen metabolic process; collagen fibril organization;
	Sumber:Amigo / QuickGO
Ortologi
	1545
	13078
	ENSG00000138061
	ENSMUSG00000024087
	Q16678
	Q64429
	NM_000104
	NM_009994; NM_001364889
	NP_000095
	NP_034124; NP_001351818
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Sitokrom P450 1B1 adalah enzim yang pada manusia disandi oleh gen CYP1B1.^[3]

Fungsi

CYP1B1 termasuk dalam superfamili enzim sitokrom P450. Protein sitokrom P450 adalah monooksigenase yang mengatalisis banyak reaksi yang terlibat dalam metabolisme obat serta sintesis kolesterol, steroid, dan lipid lainnya. Enzim yang disandi oleh gen ini terlokalisasi pada retikulum endoplasma (ER) dan memetabolisme prakarsinogen seperti hidrokarbon aromatik polisiklik dan 17beta-estradiol.

Meskipun telah ada penelitian selama lebih dari 20 tahun mengenai CYP1A1 dan CYP1A2, CYP1B1 baru diidentifikasi dan diurutkan pada tahun 1994. Analisis asam nukleat dan asam amino menunjukkan identitas sekitar 40% dengan CYP1A1. Terlepas dari kemiripan ini, kedua enzim tersebut memiliki efisiensi katalitik dan metabolit yang sangat berbeda ketika diinkubasi dengan substrat umum, seperti asam retinoat dan asam arakidonat. Baru-baru ini, CYP1B1 terbukti memiliki peran fisiologis penting dalam perkembangan janin, karena mutasi pada CYP1B1 dikaitkan dengan salah satu bentuk glaukoma kongenital primer.

CYP1A1 dan CYP1B1 diatur oleh reseptor aril hidrokarbon, sebuah faktor transkripsi yang diaktivasi oleh ligan. Keduanya merupakan bagian dari reaksi Fase I metabolisme obat.

Signifikansi klinis

Mutasi pada gen ini telah dikaitkan dengan glaukoma kongenital primer; oleh karena itu, diperkirakan bahwa enzim ini juga memetabolisme molekul sinyal yang terlibat dalam perkembangan mata, kemungkinan berupa steroid.^[3]

P450 diekspresikan secara tinggi pada tumor dan terlibat dalam resistensi obat, serta menjadi target penelitian untuk memerangi kanker. Inhibitor yang telah dikembangkan meliputi flavonoid, trans-stilbene, kuinazolin, dan turunan dari bentranil, sebuah herbisida.^[4]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Templat:NCBI RefSeq
^ Yi L, Huang X, Yang M, Cai J, Jia J, Peng Z, et al. (January 2023). "A new class of CYP1B1 inhibitors derived from bentranil". Bioorganic & Medicinal Chemistry Letters. 80 129112. doi:10.1016/j.bmcl.2022.129112. PMID 36565966.

Bacaan lebih lanjut

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Stoilov I, Akarsu AN, Sarfarazi M (Apr 1997). "Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21". Human Molecular Genetics. 6 (4): 641–647. doi:10.1093/hmg/6.4.641. PMID 9097971.
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