ERG11
| Sterol 14-demethylase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organisme | |||||||
| Simbol | ERG11 | ||||||
| Symbols alternatif | CYP51F1 | ||||||
| Entrez | 856398 | ||||||
| HomoloGene | 55488 | ||||||
| RefSeq (mRNA) | NM_001179137 | ||||||
| RefSeq (Prot) | NP_011871 | ||||||
| UniProt | P10614 | ||||||
| Other data | |||||||
| EC number | 1.14.14.154 | ||||||
| Chromosome | VIII: 0.12 - 0.12 Mb | ||||||
| |||||||
ERG11 atau sterol 14-demetilase adalah enzim sitokrom P450 jamur yang berasal dari Saccharomyces cerevisiae, termasuk dalam famili CYP51, dengan Simbol CYP CYP51F1.[1] ERG11 mengatalisis C14-demetilasi lanosterol menjadi 4,4'-dimetil kolesta-8,14,24-triena-3-beta-ol yang merupakan langkah pertama biosintesis zimosterol, yang nantinya akan diubah lebih lanjut menjadi ergosterol.[2]
Referensi
- ^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. (October 2003). "Global analysis of protein expression in yeast". Nature. 425 (6959): 737–41. Bibcode:2003Natur.425..737G. doi:10.1038/nature02046. PMID 14562106. S2CID 4344864.
- ^ Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research. 46 (9): 1991–8. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.
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