Enotikumab

Enotikumab
Antibodi monoklonal
JenisWhole antibody
SumberTemplat:Infobox drug/mab source
TargetDLL4
Data klinis
Nama lainREGN421
Kode ATC
  • none
Pengenal
Nomor CAS
ChemSpider
  • none
UNII
KEGG

Enotikumab (REGN421, INN) adalah antibodi monoklonal manusia yang mengikat DLL4. Ia bertindak sebagai imunomodulator.[1][2][3][4][5]

Referensi

  1. ^ World Health Organization (2012). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2).
  2. ^ Huang J, Hu W, Hu L, Previs RA, Dalton HJ, Yang XY, Sun Y, McGuire M, Rupaimoole R, Nagaraja AS, Kang Y, Liu T, Nick AM, Jennings NB, Coleman RL, Jaffe RB, Sood AK (June 2016). "Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth". Mol. Cancer Ther. 15 (6): 1344–52. doi:10.1158/1535-7163.MCT-15-0144. PMC 4893925. PMID 27009216.
  3. ^ Kuhnert F, Chen G, Coetzee S, Thambi N, Hickey C, Shan J, Kovalenko P, Noguera-Troise I, Smith E, Fairhurst J, Andreev J, Kirshner JR, Papadopoulos N, Thurston G (October 2015). "Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer". Cancer Res. 75 (19): 4086–96. doi:10.1158/0008-5472.CAN-14-3773. PMID 26377940.
  4. ^ Chiorean EG, LoRusso P, Strother RM, Diamond JR, Younger A, Messersmith WA, Adriaens L, Liu L, Kao RJ, DiCioccio AT, Kostic A, Leek R, Harris A, Jimeno A (June 2015). "A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors". Clin. Cancer Res. 21 (12): 2695–703. doi:10.1158/1078-0432.CCR-14-2797. PMID 25724527.
  5. ^ Miles KM, Seshadri M, Ciamporcero E, Adelaiye R, Gillard B, Sotomayor P, Attwood K, Shen L, Conroy D, Kuhnert F, Lalani AS, Thurston G, Pili R (2014). "Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts". PLOS ONE. 9 (11) e112371. Bibcode:2014PLoSO...9k2371M. doi:10.1371/journal.pone.0112371. PMC 4231048. PMID 25393540.
Ikon rintisan

Artikel bertopik farmakologi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
Kembali kehalaman sebelumnya