Interleukin-4

Interleukin-4
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Pengidentifikasi
Alias	IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
ID Eksternal	MGI: 96556; HomoloGene: 491; GeneCards: IL4; OMA:IL4 - orthologs
Lokasi gen (Manusia)
Kr.	Kromosom 5 (manusia)
Akhir	132,018,370 pb
Pola ekspresi RNA
	Ekspresi tertinggi di
	oosit; ; secondary oocyte; ; Testis; ; Gonad; ; right uterine tube; ; Monosit; ; Adenohipofisis; ; right coronary artery; ; olfactory zone of nasal mucosa; ; bone marrow cell;
	Ekspresi tertinggi di
	neural layer of retina; ; superior frontal gyrus; ; spermatocyte; ; primary visual cortex; ; Lensa mata; ; embrio; ; embrio; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; morula;
	Referensi data ekspresi selengkapnya
	n/a
Ontologi gen
Fungsi molekuler	interleukin-4 receptor binding; Ikatan protein plasma; growth factor activity; cytokine receptor binding; cytokine activity;
Komponen seluler	extracellular region; extracellular space;
Proses biologis	positive regulation of T cell differentiation; dendritic cell differentiation; negative regulation of endothelial cell apoptotic process; negative regulation of complement-dependent cytotoxicity; regulation of phosphorylation; negative regulation of apoptotic process; myeloid dendritic cell differentiation; type 2 immune response; B cell activation; positive regulation of interleukin-13 production; respons imun; B cell differentiation; T-helper 2 cell cytokine production; regulation of isotype switching; negative regulation of transcription, DNA-templated; negative regulation of epithelial cell migration; regulation of signaling receptor activity; cholesterol metabolic process; positive regulation of B cell proliferation; positive regulation of T cell proliferation; T cell activation; positive regulation of MHC class II biosynthetic process; negative regulation of osteoclast differentiation; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; regulation of immune response; cytokine-mediated signaling pathway; positive regulation of gene expression; positive regulation of macroautophagy; positive regulation of tyrosine phosphorylation of STAT protein; activation of Janus kinase activity; positive regulation of receptor-mediated endocytosis; positive regulation of cold-induced thermogenesis; negative regulation of neuroinflammatory response; positive regulation of amyloid-beta clearance; neuroinflammatory response; positive regulation of cellular respiration; positive regulation of ATP biosynthetic process;
	Sumber:Amigo / QuickGO
Ortologi
	3565
	16189
	ENSG00000113520
	ENSMUSG00000000869
	P05112
	P07750
	NM_000589.4
	NM_021283
	NP_000580; NP_758858; NP_001341919
	NP_067258
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-4, IL-4 (bahasa Inggris: BSF1, BCGF1, BCGF-1, MGC79402code: en is deprecated ) adalah sitokina pleiotropik yang disekresi oleh sel T yang telah teraktivasi^[3] menjadi sel T_H2, bersama-sama dengan IL-5 dan IL-13.^[4] IL-4 berperan dominan dalam sistem kekebalan dan merupakan faktor yang penting dalam perkembangan hipersensitivitas,^[5] dengan fungsi seluler yang banyak tumpang-tindih dengan IL-13.^[3]

Rujukan

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b (Inggris) "IL4 interleukin 4 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-09.
^ (Inggris) "Inflammatory cytokines (IL-4, IL-5 and IL-13)". Clinical Research Center, National Sagamihara Hospital; Maeda S, Yanagihara Y. Diakses tanggal 2010-06-09.
^ (Inggris) "A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor". Lehrstuhl für Physiologische Chemie II, Theodor-Boveri Institut für Biowissenschaften (Biozentrum) der Universität Würzburg; Kraich M, Klein M, Patiño E, Harrer H, Nickel J, Sebald W, Mueller TD. Diakses tanggal 2010-06-09.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez3565-3] (Inggris) "IL4 interleukin 4 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-09.

[4] (Inggris) "Inflammatory cytokines (IL-4, IL-5 and IL-13)". Clinical Research Center, National Sagamihara Hospital; Maeda S, Yanagihara Y. Diakses tanggal 2010-06-09.

[5] (Inggris) "A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor". Lehrstuhl für Physiologische Chemie II, Theodor-Boveri Institut für Biowissenschaften (Biozentrum) der Universität Würzburg; Kraich M, Klein M, Patiño E, Harrer H, Nickel J, Sebald W, Mueller TD. Diakses tanggal 2010-06-09.

[1]

[2]

[3]

[4]

[5]

Interleukin-4

Rujukan

Content Disclaimer