Reaksi Ivanov

Reaksi Ivanon adalah reaksi kimia dari dianion aril asam asetat (reagen Ivanov) dengan elektrofil, utamanya adalah senyawa karbonil atau isosianat.[1][2][3][4] Reaksi ini dinamakan dari kimiawan organik Bulgaria, Dimitar Ivanov Popov.

Reaksi Ivanov
Reaksi Ivanov

Reagen Ivanov 1 (dianion aril asam asetat) dapat bereaksi dengan banyak elektrofil, meliputi aldehida, keton, isosianat, dan alkil halida.[5] Produk reaksi biasanya tidak akan mengalami dekarboksilasi secara spontan, tetapi hal ini dimungkinkan dengan menggunakan reagen-reagen tertentu.

Reagen Ivanov 1

Reaksi Ivanov dikenal berjalan melalui keadaan transisi model Zimmerman-Traxler. Toulec dkk. telah menginvestigasi laju dan kinetika reaksi ini.[6]

Referensi

  1. ^ Ivanov, D.; Spassoff, A. Bull. Soc. Chim. France 1931, 49, 19 & 375.
  2. ^ Ivanov, D. et al. Bull. Soc. Chim. France 1932, 51, 1321 & 1325 & 1331.
  3. ^ Blagoev, B.; Ivanov, D. Synthesis 1970, 615-627. (Review)
  4. ^ Ivanov, D. Synthesis 1975, 83-98. (Review)
  5. ^ Hauser, C. R.; Dunnavant, W. R. (1960). "α,β-Diphenylpropionic acid". Organic Syntheses. 40: 38. Pemeliharaan CS1: Banyak nama: authors list (link)
  6. ^ Toullec, J.; Mladenova, M.; Gaudemar-Bardone, F.; Blagoev, B. J. Org. Chem. 1985, 50, 2563.

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