Pallante signed with the Cardinals and made his professional debut with the State College Spikes of the Class A Short SeasonNew York–Penn League, going 1–0 with a 2.78 ERA over 35+2⁄3 innings.[11] He did not play a minor league game in 2020 due to the cancellation of the minor league season caused by the COVID-19 pandemic.[12] For a majority of the 2021 season, Pallante played with the Springfield Cardinals of the Double-A Central and started 21 games in which he went 4–7 with a 3.82 ERA and 82 strikeouts over 94+1⁄3 innings.[13] After the end of Springfield's season in mid-September, he was promoted to the Memphis Redbirds of the Triple-A East, with whom he appeared in two games.[14] He was selected to play in the Arizona Fall League for the Glendale Desert Dogs after the season where he was named to the Fall Stars Game.[15]
St. Louis Cardinals
Andre Pallante with St.Louis in 2024
Pallante was a non-roster invitee to spring training in 2022, and on April 4, the Cardinals announced that he had been named to the Opening Day roster.[16] He made his MLB debut on April 10 versus the Pittsburgh Pirates, throwing one inning in relief and giving up one earned run.[17] In early June, he moved into the starting rotation.[18]