Antichan-de-Frontignes is located at the foot of the Pyrenees in the Comminges region some 40 km east by south-east of Bagnères-de-Bigorre and 19 km south by south-west of Saint-Gaudens. Access to the commune is by the D618 road which branches from the D331 east of Ore and goes to the village then continues north-east by a roundabout route to Juzet-d'Izaut. There is also a local road going from the D618 north of the village to Saint-Pé-d'Ardet. Most of the commune is heavily forested however there is some farmland near the village.[3]
The village is the point of departure for a hiking trail which crosses the Col des Ares 4.5 km from the village then continues to the summits of the Pic du Gar and the Saillant Peak.