Jenkins was drafted by the Green Bay Packers with the 44th overall pick in the second round of the 2019 NFL draft.[4] He signed his four-year rookie contract on May 13, 2019,[5] worth $6.782 million.[6] After entering his rookie season as a backup, Jenkins made his first NFL start on September 22, 2019, in a Week 3 game against the Denver Broncos, replacing an injured Lane Taylor.[7] On 571 pass-blocking snaps this season, Jenkins did not allow a single sack. During the 2020 season, he earned his first Pro Bowl nod as a starter.[8]
Jenkins entered the 2021 season as the Packers starting left tackle in place of an injured David Bakhtiari. He started eight games there before suffering a torn ACL in Week 11 of a 34–31 loss to the Minnesota Vikings.[9] The Packers placed him on injured reserve two days later, ending his season.[10]
On December 23, 2022, Jenkins signed a four-year, $68 million contract extension.[11][12] He was named as an alternate to the 2023 Pro Bowl.[13]