Reynolds read comics from an early age, and remembers being fascinated by a stack of Superman comics he saw when he was young.[4]
Reynolds was moving towards a career in journalism when he was in university in California and was managing editor and cartoonist for his university newspaper. In the spring of 1993, he realized that Fantagraphics published almost all of his favorite comics. He contacted them looking for a job. He got a job a month later, and stayed in Seattle for three months before returning to university. After finishing his degree a semester later, he returned to Fantagraphics and has remained there ever since.[4]
Reynolds worked as news editor for The Comics Journal from 1993, covering such events as the rise of Image Comics, the Mike Diana controversies and the general downturn in the comic book industry, before moving to marketing and promotion in 1996.[2]
His name was given to a character who worked for a comic book publisher in an episode of The Simpsons in 2000 by writer and producer Dana Gould.[5] In 2018 he was the recipient of an Inkpot Award from Comic-Con International.