François-Poncet had served as a diplomat in the government in the 1950s and 1960s. "Entering politics in 1967, he was elected in Lot-et-Garonne, as [a] member of the general council".[5] François-Poncet served as CEO of Carnaud SA, a major packaging business, from 1971 to 1974. He returned to government service in 1974 when President Valéry Giscard d'Estaing appointed François-Poncet secretary of state at the Ministry of Foreign Affairs. In 1976 President Giscard d'Estaing appointed François-Poncet Secretary General in the Office of the President, "a key post in French politics".[6] In 1978 d'Estaing appointed François-Poncet Minister of Foreign Affairs. He held the latter position until 1981.[5]
In the 1980s he participated in three conferences of the Bilderberg group (in 1982, 1985 and 1988).
In 1983, he was elected senator from the Department of Lot-et-Garonne. François-Poncet served in the Senate until 2010, where he chaired the Economic Affairs Committee until 2001 and also served as Vice President of the Foreign Relations and Defense Committee as well as Vice President of the Senatorial European Affairs Committee. "He led Senate delegations in Eastern Europe, South-East Asia, China, Central Asia, Afghanistan, and most Middle Eastern countries."
[5]
He was the son of André François-Poncet, also a French politician and diplomat, whose diplomatic post as French Ambassador to Germany allowed him to witness the rise to power of Adolf Hitler and the Nazi Party, as well as the Third Reich's preparations for war.