As a freshman, Reed served as the Cavaliers' primary kick returner and returned 28 kicks for 678 yards total (25.1 average).[3] As a sophomore, he returned 29 kicks for 861 yards with two touchdowns and caught 23 passes for 244 yards and two touchdowns while also rushing for one touchdown and was named honorable mention All-Atlantic Coast Conference (ACC) as a return specialist.[4][5] Reed was named third-team All-ACC after finishing his junior season with 25 receptions for 465 yards and seven touchdowns and 707 yards and a touchdown on 26 kickoff returns.[6] As a senior, Reed returned 24 kickoffs for 796 yards (33.2 yards per return) and two touchdowns and was named first-team All-ACC as an all-purpose performer and as a return specialist, as well as a first-team All-American by the Walter Camp Foundation and the Football Writers Association of America and won the Jet Award as the nation's top return specialist.[7][8] Reed also led Virginia with 77 receptions for 679 yards and seven touchdowns.[9]
On August 31, 2021, Reed was waived by the Chargers and re-signed to the practice squad the next day.[14][15] He signed a reserve/future contract with the Chargers on January 18, 2022.
On August 30, 2022, Reed was waived by the Chargers and signed to the practice squad the next day.[16][17]