Lortalamine
Chemical compound
Lortalamine (LM-1404 ) is an antidepressant which was synthesized in the early 1980s.[1] [2] It acts as a potent and highly selective norepinephrine reuptake inhibitor .[3] [4] Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals.[5] [6] It has been used to label the norepinephrine transporter in positron emission tomography studies.[4] [7] [8]
See also
References
^ David J. Triggle (1997). Dictionary of pharmacological agents . London: Chapman & Hall. ISBN 0-412-46630-9 .
^ Belleville M, Grand M, Briet P (1981). "Plasma levels, elimination and metabolic fate of 4a-amino-8-chloro-2-methyl-1,2,3,4,4a,10a-hexahydro-10H-benzopyrano[3,2-c]pyridin-10-ylacetic acid lactam, a new antidepressive agent, in rats and dogs" . Drug Metabolism and Disposition . 9 (3): 233–9. PMID 6113932 .
^ Depin JC, Betbeder-Matibet A, Bonhomme Y, Muller AJ, Berthelon JJ (1985). "Pharmacology of lortalamine, a new potent non-tricyclic antidepressant". Arzneimittel-Forschung . 35 (11): 1655–62. PMID 4091869 .
^ a b Lin KS, Ding YS (August 2005). "Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons" . Bioorganic & Medicinal Chemistry . 13 (15): 4658–66. doi :10.1016/j.bmc.2005.04.062 . PMID 15914010 .
^ Elsom LF, Biggs SR, Chasseaud LF, Hawkins DR, Pulsford J, Darragh A (1985). "Metabolism of the anti-depressant lortalamine". European Journal of Drug Metabolism and Pharmacokinetics . 10 (3): 209–15. doi :10.1007/bf03189744 . PMID 4085522 . S2CID 2196891 .
^ Mally C, Thiebault JJ (1990). "Ocular toxicity in beagle dogs with lortalamine, a non tricyclic antidepressant compound". Drug and Chemical Toxicology . 13 (4): 309–23. doi :10.3109/01480549009032289 . PMID 2279460 .
^ Ding YS, Lin KS, Logan J, Benveniste H, Carter P (July 2005). "Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine" . Journal of Neurochemistry . 94 (2): 337–51. doi :10.1111/j.1471-4159.2005.03202.x . PMID 15998285 . S2CID 25110597 .
^ Ding YS, Lin KS, Logan J (2006). "PET imaging of norepinephrine transporters" . Current Pharmaceutical Design . 12 (30): 3831–45. doi :10.2174/138161206778559687 . PMID 17073682 .
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