In Week 3 of the 2020 season against the Denver Broncos, Edwards recorded his first career interception off a pass thrown by Brett Rypien late in the fourth quarter to secure a 28–10 Buccaneers win.[4] In the Divisional Round of the playoffs against the New Orleans Saints, Edwards intercepted a pass thrown by Drew Brees during the 30–20 win.[5] Edwards earned his first Super Bowl ring when the Buccaneers defeated the Kansas City Chiefs in Super Bowl LV.[6]
In Week 2 of the 2021 season against the Atlanta Falcons, Edwards recorded four tackles, three pass deflections, and two interceptions returned for touchdowns from Matt Ryan in a 48–25 win.[7] As a result of his performance in Week 2, Edwards was named NFC Defensive Player of the Week.[8] On December 2, 2021, Edwards was suspended for three games by the NFL for violating the league's COVID-19 protocols after he misrepresented his vaccination status.[9]
Kansas City Chiefs
Edwards signed a one-year contract with the Chiefs on March 20, 2023.[10] In Edwards lone season with the Chiefs, he recorded 51 tackles, one sack, two fumble recoveries, one interception, and five passes defended. In the Wild Card victory over the Miami Dolphins, Edwards recorded an interception. In the Divisional round against the Buffalo Bills, Edwards left the game with a concussion. Edwards returned for the AFC Championship Game against the Baltimore Ravens where the Chiefs won and advanced to Super Bowl LVIII. In the Super Bowl, Edwards recorded 7 tackles and 1 pass defended in the Chiefs 25-22 victory over the San Francisco 49ers.[11]
Buffalo Bills
On March 20, 2024, Edwards signed a one–year contract with the Buffalo Bills.[12]