Mizque is located on a well maintained highway which to the north-west leads through the Valle Alto to Cochabamba. In the other direction, as National Road 23, the route runs southwards to Aiquile and, beyond that, to Sucre.
The bus connection to Cochabamba operates on an almost daily basis.
Mizque is also positioned beside the Cochabamba-Aiquile railway line, but since the railway station is across the river it is hard for the inhabitants to access. There is a railcar service to Cochabamba that runs three times per week, but the journey time is approximately twice as long as that taken by the bus using the main road, and the station is not much used for passenger traffic.