During his junior year, Uihlein won the Ben Hogan Award, given to the best college golfer in the nation. He was also named a first team All-American. Uihlein tried unsuccessfully to defend his U.S. Amateur title in 2011 when he lost in the quarterfinals.[12] He played the European and PGA Tour qualifying schools in 2011, but failed to earn tour cards on either tour. He decided to turn professional in December 2011.[13]
Professional career
Uihlein finished in a tie for 12th at his first professional event on the Challenge Tour at the 2012 Gujarat Kensville Challenge. Uihlein has also played on the Sunshine Tour, where he finished T4 at the 2013 Tshwane Open, an event co-sanctioned with the European Tour. Uihlein earned his first professional win in 2013 at the Madeira Islands Open, a dual-ranked event on the European Tour and Challenge Tour.[14] He ranked 14th in the 2013 Race to Dubai money list with eight top-10 finishes, and was named the European Tour's Sir Henry Cotton Rookie of the Year.
In 2017, Uihlein played the Puerto Rico Open on the PGA Tour via a sponsor's exemption and finished fifth.[15] A week later, he finished 23rd at the Shell Houston Open. These earned him enough FedEx Cup points for a place in the 2017 Web.com Tour Finals. He won the first tournament to earn a place on the PGA Tour for 2017–18.
Uihlein played 26 events on the 2017–18 PGA Tour, making the cut 16 times. He had eight top-25 finishes, four top-10 finishes, and three top-five finishes. In round three of the Wells Fargo Championship, he had a birdie/eagle streak of 7-under on six holes, which tied him with Jonathan Randolph for the longest streak on the PGA Tour for the 2017–18 PGA season. He finished at number 64 in the FedEx Cup standings, qualifying him for the FedEx Cup playoffs in his rookie season, winning $1.8 million for the season.
During the 2018–19 season, Uihlein played a total of 29 events on the PGA Tour. His best results were a T7 at the RSM Classic in November 2018, and a T5 in May 2019 at the AT&T Byron Nelson tournament. He won $840,000 during the season, finishing at number 133 in the FedEx Cup standings.
In 2021, Uihlein won his second Korn Ferry Tour event at the MGM Resorts Championship. He would go on to earn his PGA Tour card for 2022 with a Top 25 finish in the Korn Ferry Tour Finals.
On June 9, 2022, Uihlein was one of 17 PGA Tour members suspended for playing in the Saudi-backed LIV Golf.[16]
In 2023, Uihlein competed as part of 4Aces GC in the 2023 LIV Golf League. He finished in 12th place in the individual standings, and had a season-best finish of 2nd place at the opening event of the season at Mayakoba. He also had three other top-ten finishes on the season. After the season, Uihlein was re-signed by the 4Aces, but was traded to RangeGoats GC on December 7, 2023.