On June 11, 2015, the Nationals traded Renda to the New York Yankees in exchange for David Carpenter.[11] The Yankees assigned Renda to the Trenton Thunder of the Eastern League.[12] Renda played 73 games for Trenton, batting .270 with two home runs and 21 RBIs.
The Reds promoted Renda to the major leagues on August 2.[15] He made his major league debut that day,[1] and got his first major league hit in his first at bat off Jonathan Broxton of the St. Louis Cardinals, an infield bunt single.[16] The hit was first recorded as a sacrifice bunt and error, but was changed to a hit several days later.[17] Overall, with the 2016 Reds, Renda appeared in 32 games, batting .183 (11-for-60) with three RBIs.
Renda began the 2017 season with Triple-A Louisville, appearing in 51 games with a .260 average.
Arizona Diamondbacks
On July 3, 2017, the Cincinnati Reds traded Renda to the Arizona Diamondbacks for a player to be named later.[18] He was assigned to the Reno Aces of the Triple-A Pacific Coast League, batting .185 (5-for-27) in eight games, spending mid-July though late September on the disabled list.[19] Renda was released prior to the 2018 season.
Boston Red Sox (2018)
On April 30, 2018, Renda signed a minor league contract with the Boston Red Sox. He was assigned to the Double-A Portland Sea Dogs where he hit .371 in 26 games; he was promoted to the Triple-A Pawtucket Red Sox in mid-July.[19] Renda was called up to Boston on August 4, after Ian Kinsler was placed on the 10-day disabled list and Dustin Pedroia was moved to the 60-day disabled list, opening a spot on the 40-man roster for Renda.[20] In an August 5 game against the rivalNew York Yankees, Renda pinch ran and scored the winning run in a 5–4 Red Sox comeback, driven in on a single by Andrew Benintendi in the 10th inning.[21] Renda was optioned back to Triple-A on August 8, without making another appearance.[20] Renda was outrighted to the minors on November 1, removing him from the 40-man roster; he elected free agency on November 2. Renda is a member of the 2018 World Champion Red Sox.
On November 29, 2018, Renda re-signed to a minor league deal with the Red Sox.[22] He started the 2019 season with Triple-A Pawtucket, batting .200 (4-for-20) in five games.[19] He was placed on the injured list in mid-April with a right shoulder strain, and missed the rest of the season.[19] He became a free agent after the 2019 season.