Class of enzymes
The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction
3-hydroxy-2-methylpropanoyl-CoA + H2 O
⇌ ⇌ -->
{\displaystyle \rightleftharpoons }
CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of hydrolases , specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase . Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase , and HIB CoA deacylase . This enzyme participates in 3 metabolic pathways : valine, leucine and isoleucine degradation , β-alanine metabolism , and propanoate metabolism . 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[ 1]
References
Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids". The Journal of Biological Chemistry . 225 (1): 523–34. PMID 13457352 .
Activity Regulation Classification Kinetics Types