CLIC4

CLIC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AHE, 2D2Z, 3OQS
Identifiers
Aliases	CLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDs	OMIM: 606536; MGI: 1352754; HomoloGene: 8490; GeneCards: CLIC4; OMA:CLIC4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,844,321 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,000,125 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; tail of epididymis; ; popliteal artery; ; tibial arteries; ; vena cava; ; Descending thoracic aorta; ; smooth muscle tissue; ; ascending aorta; ; right coronary artery; ; urethra;
	Top expressed in
	gastrula; ; right lung; ; right lung lobe; ; decidua; ; ascending aorta; ; cardiac muscle tissue of left ventricle; ; sciatic nerve; ; semi-lunar valve; ; left lung; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	voltage-gated ion channel activity; protein binding; glutathione transferase activity; chloride channel activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; centrosome; membrane; cell-cell junction; nuclear matrix; microtubule cytoskeleton; plasma membrane; apical part of cell; intracellular anatomical structure; chloride channel complex; microtubule organizing center; microvillus; cell surface; cell junction; midbody; mitochondrion; actin cytoskeleton; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic vesicle; nucleus;
Biological process	cellular response to calcium ion; cell differentiation; multicellular organism growth; regulation of ion transmembrane transport; endothelial cell morphogenesis; ion transport; keratinocyte differentiation; vacuolar acidification; negative regulation of cell migration; fertilization; establishment or maintenance of apical/basal cell polarity; chloride transport; branching morphogenesis of an epithelial tube; retina vasculature morphogenesis in camera-type eye; regulation of cytoskeleton organization; angiogenesis; glutathione metabolic process; chloride transmembrane transport; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	25932
	29876
	ENSG00000169504
	ENSMUSG00000037242
	Q9Y696
	Q9QYB1
	NM_013943
	NM_013885
	NP_039234
	NP_038913
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.^[5]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).^[5]