The histocompatibility 60 (H60) was originally identified as a transplant rejection antigen[1] and it is a family of murine cell surface glycoproteins contains three members: H60a, H60b, H60c. The genes encoding these proteins are located on murine chromosome 10.[2] H60 family members are related to MHC class I.[2][3] H60a and H60b consist of external α1α2 domain, a transmembrane segment, and a cytoplasmic domain.[2][3] H60c is made up of α1α2 domain which is linked to the cell membrane by GPI anchor.[2] All these proteins function as stress-induced ligands for NKG2D receptor.[2][3]