In late 1955, Ambrose was one of the co-founders of Systems Research Corporation. Systems Research Corporation was subsequently acquired by the Ford Motor Company, laying the foundation for what would become Ford Aerospace. Ambrose worked in management at Ford Aerospace for thirty-six years. He worked mainly on technical aspects of defense systems, space programs, and communications, command, and control systems. From 1968 to 1981, Ambrose held the title of Vice President for Technical Affairs of Ford Aerospace.