Butcher was the opposing pitcher on June 15, 1938, when left-hander Johnny Vander Meer of the visiting Cincinnati Reds threw a second consecutive no-hitter, a feat never duplicated in Major League Baseball since. Butcher was the starting pitcher for Brooklyn in front of an uncommonly large crowd of 38,748, it also being the first night game played at Ebbets Field.
Butcher bounced back from a 17-loss 1939 season in 1941 with a 17–12 record for the Pirates that included 19 complete games. In 1944, he went 13–11 for Pittsburgh and ranked among the league leaders in shutouts with five.