Natasha Gregson was born September 29, 1970, in Los Angeles, to American actress Natalie Wood and British producer Richard Gregson.[2] Her godmother was actress Ruth Gordon.[3] Her parents separated when she was ten months old, and later divorced.[4] Her mother remarried actor Robert Wagner in 1972, and in 1974 they had a daughter, Courtney.[3] Her aunt, with whom she has no contact,[5] is actress and producer Lana Wood. Through her father, she is a cousin of author Jessica Gregson, niece of actor Michael Craig, stepdaughter of journalist Julia Gregson and great-great granddaughter of Reginald Hanson, former Lord Mayor of London.[6] She is distantly related by marriage to baseball player Tim Lincecum on her mother's side.[7]
On November 29, 1981, Natalie Wood drowned near Santa Catalina Island.[2] After her mother's death, Gregson Wagner and her half-sister were raised in California by Wagner and actress Jill St. John.[3][8]
In 2000, Gregson Wagner had roles in Stranger Than Fiction, and High Fidelity opposite John Cusack. In 2001, she was regular cast member in the short-lived prime time soap opera, Pasadena.[11] In 2003, she played Barbara Richardson in the movie Wonderland. In 2004, she had a role in the Hallmark movie, Angel in the Family playing the part of Beth. In 2005 Gregson Wagner guest-starred on Cold Case and Medium. In 2006, she starred in two episodes of ER: "Bloodline" and "21 Guns". From 2005 to 2007, she had a recurring role on the TV show The 4400 as April Skouris, the sister of NTAC agent Diana Skouris. In 2008, she guest starred on CSI: Crime Scene Investigation and House M.D.
From 1990 to 1997, Gregson Wagner dated Josh Evans, son of Ali MacGraw and Robert Evans.[14] She was married to screenwriter D.V. DeVincentis from October 2003 to January 2008.[15]
On May 30, 2012, Gregson Wagner and actor Barry Watson had a daughter, Clover Clementyne Watson.[16] The couple married in December 2014.[17]