Siragusa was a four-year starter at San Diego State. On November 14, 2016, it was announced that Siragusa had accepted an invitation to appear in the 2017 Senior Bowl.[2] He attended the Senior Bowl, but suffered a thumb injury on the first day of practice that sidelined him for the rest of the week and the Reese's Senior Bowl game.[3]
The Baltimore Ravens selected Siragusa in the fourth round (122nd overall) of the 2017 NFL Draft.[5] He was the sixth guard and eighth interior offensive lineman, as well as one of three San Diego State products (along with Donnel Pumphrey and Damontae Kazee) selected in 2017.[6][7] On May 5, 2017, the Ravens signed Siragusa to a four-year, $3.02 million contract, including a $628,379 signing bonus.[8] However, during a training camp practice on August 1, Siragusa tore his ACL, MCL, and PCL. He was placed on injured reserve on September 1, 2017, ending his rookie season before it began.[9][10]
On September 1, 2018, the Ravens waived Siragusa during final roster cuts and resigned him to the practice squad the next day.[11][12]
Green Bay Packers
On December 12, 2018, the Green Bay Packers signed Siragusa off the Ravens' practice squad and added him to their active roster after placing Byron Bell on injured reserve.[13] He was waived on April 29, 2019.[14]
On August 1, 2019, Siragusa signed with the Buffalo Bills, but was waived nine days later.[17][18]
Los Angeles Wildcats
Siragusa was drafted by the Los Angeles Wildcats of the XFL in the 6th round in phase two of the 2020 XFL Draft.[19] He had his contract terminated when the league suspended operations on April 10, 2020.[20]
Personal life
Despite his surname and the team that drafted him, Nico is not related to former Ravens defensive tackle Tony Siragusa.[21] His parents are Ramon and Dianne Siragusa.[22]