Amuge Otengo began her career in 1991 as the Personnel Manager/Trainer at Sun-Set Group, serving in that capacity until 1993. She then worked as a personnel instructor at the Church of Uganda provincial project in Jinja, from 1993 until 1995. Between 1996 and 2001 she was the Project Coordinator at Church of Uganda, Lango Diocese. From 2002 until 2006, she served as the Vice Chairperson of Lango District Local Government. In 2006, she was elected to Parliament to represent women in Lira District, serving from 2006 until 2011. In 2011 she contested for the parliamentary seat of Women's Representative for newly created Alebtong District and was elected.[6] In May 2011, she was appointed Minister of State for Northern Uganda;[7] she replaced David Wakinona, who was appointed State Minister for Trade and Antiquities.