Secobarbital/brallobarbital/hydroxyzine was a combination tablet containing 50 mg brallobarbital, 150 mg secobarbital and 50 mg hydroxyzine[1] that was used as a sedative. It was sold under the brand name Vesparax. This drug has been withdrawn from the market in most countries.
Hydroxyzine and secobarbital lengthen the half-life of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.[2][3]
Jimi Hendrix was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.[4]
References
^Lhermann J (March 1964). "[Clinical Application of a New Very Active Hypnotic Associating Sodium Secobarbital, Calcium Brallobarbital and Hydroxyzine (Uc-8130)]". Gazette Médicale de France. 71: 961–2. PMID14142825.
^Yih TD, Rossum JM (June 1976). "Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 6 (6): 355–62. doi:10.3109/00498257609151647. PMID969563.