In 2003 it failed a phase II clinical trial for metastatic colorectal cancer.[3]
References
^Scott AM, Wiseman G, Welt S, Adjei A, Lee FT, Hopkins W, et al. (May 2003). "A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer". Clinical Cancer Research. 9 (5): 1639–47. PMID12738716.
^Kloft C, Graefe EU, Tanswell P, Scott AM, Hofheinz R, Amelsberg A, Karlsson MO (January 2004). "Population pharmacokinetics of sibrotuzumab, a novel therapeutic monoclonal antibody, in cancer patients". Investigational New Drugs. 22 (1): 39–52. doi:10.1023/B:DRUG.0000006173.72210.1c. PMID14707493. S2CID24877721.
^Hofheinz RD, al-Batran SE, Hartmann F, Hartung G, Jäger D, Renner C, et al. (February 2003). "Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer". Onkologie. 26 (1): 44–8. doi:10.1159/000069863. PMID12624517. S2CID29922209.