Opher, originally from Oxfordshire, attended to a comprehensive school before studying medicine at St Mary's Hospital Medical School in London. Prior to becoming and MP he worked and lived in Dursley as a full-time GP for "almost exactly 29 years," with his wife Rachel; their three children attended the local Rednock School. He was awarded an MBE in 2016 for introducing and advocating social prescribing (now part of NHS policy nationwide) and was instrumental in the building of the Vale Community Hospital. Chairman of the Stroud Locality NHS, Opher headed the Covid-19 vaccination program locally and pledged to keep a day a week for patients in his practice after his election, a promise he renewed after his election.[2]