After signing, Scott made his professional debut with the Gulf Coast Orioles and spent the whole season there, going 1-5 with a 6.26 ERA in ten games (eight starts). In 2015, Scott pitched for both the Aberdeen IronBirds and Delmarva Shorebirds,[4] where he posted a combined 4-3 record and 3.83 ERA in 42.1 innings pitched between the two clubs. After the season, he pitched in the Arizona Fall League.[5] Scott spent 2016 with both the Frederick Keys and the Bowie Baysox, where he went 5-4 with a 4.76 ERA in 43 relief appearances between the two teams. In 2017, he played with Bowie where he compiled a 0-2 record and 2.22 ERA in 24 starts[6] before being called up to the major leagues on September 17, 2017.[7] Scott made two appearances for Baltimore for the season.
Scott worked regular one-inning stints for the Orioles during spring training before the 2018 season, creating speculation that the Orioles No. 6 prospect[8] could pitch his way onto the major league roster early. The plan, however, was for Scott to pitch three-inning stints as a starter in five-man rotation for the Norfolk Tides.[9]
After pitching out of the bullpen in Triple-A Norfolk's opening game on April 6, 2018, Scott was called up again on April 8 to join the Orioles bullpen — just as Jimmy Yacabonis was optioned to Norfolk.[10] Scott was optioned back to Norfolk the next day, after pitching 1+2⁄3 innings against the Yankees the day before.[11][12] He was recalled on April 20 prior to a Friday game against the Cleveland Indians.[11] Scott pitched two scoreless innings against the Indians the next day[13] before being optioned once again on April 28. Baltimore recalled him on May 9. The Orioless sent Scott down on June 9 and recalled him on June 15.[citation needed] In 53 appearances in the season, Scott worked in 53+1⁄3 innings, striking out 76 in the process.
In 2019, Scott appeared in 28 games only and posted an ERA of 4.78 in 26+1⁄3 innings with 37 strikeouts. In 2020 for the Orioles, Scott pitched to a superb 1.31 ERA to go along with 23 strikeouts in 20+2⁄3 innings pitched over 25 games. In 2021, Scott recorded a 5.17 ERA with 70 strikeouts and 37 walks in 54 innings.[14]
Miami Marlins
On April 3, 2022, the Orioles traded Scott and Cole Sulser to the Miami Marlins in exchange for a draft pick in the Competitive Balance Round B of the 2022 MLB draft, two minor league prospects, Antonio Velez and Kevin Guerrero, and a player to be named later.[15][16] (On June 3, Baltimore acquired minor league RHP Yaqui Rivera from Miami as the player to be named later).[17]
On January 13, 2023, Scott agreed to a one-year, $2.825 million contract with the Marlins, avoiding salary arbitration.[18] Scott won the National League Reliever of the Month Award for September/October.[19]