UDP-N-acetylgalactosamine-4-sulfate sulfotransferase

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UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
Identifiers
EC no.	2.8.2.7
CAS no.	37278-32-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, an UDP-N-acetylgalactosamine-4-sulfate sulfotransferase (EC 2.8.2.7) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate

\rightleftharpoons

adenosine 3',5'-bisphosphate + UDP-N-acetyl-D-galactosamine 4,6-bissulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and UDP-N-acetyl-D-galactosamine 4-sulfate, whereas its two products are adenosine 3',5'-bisphosphate and UDP-N-acetyl-D-galactosamine 4,6-bissulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase. Other names in common use include uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase, uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase, and uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase.

References

Harada T, Shimizu S, Nakanishi Y, Suzuki S (1967). "Enzymatic transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to uridine diphosphate N-acetylgalactosamine 4-sulfate". J. Biol. Chem. 242 (9): 2288–90. PMID 6022874.