Comstock was laid down on 27 October 1986, by the Avondale Shipyards, New Orleans, Louisiana; launched on 15 January 1988; and commissioned on 3 February 1990. At first USS Comstock had an all-male crew, but soon became the first United States Navy combatant ship to have a fully integrated crew of male and female sailors.
In December 2020 the U.S. Navy's Report to Congress on the Annual Long-Range Plan for Construction of Naval Vessels stated that the ship was planned to be placed Out of Commission in Reserve in 2026.[2]