ここでいう相補[13] とは、核酸塩基がワトソン・クリック型塩基対を形成していることを意味する[14]。具体的には、A (adenine, アデニン), T (tymine, チミン), G (guanine, グアニン), C (cytosine, シトシン), U (uracil, ウラシル) の5種類の天然型塩基が特定のペアー同士で水素結合によって塩基対を形成する。AとT/Uは2本の水素結合により対をなす。GとCは3本の水素結合により対をなす。したがって水素結合の数が1本多いことから、G:Cの塩基対はA:T/Uの塩基対よりも安定性が高い。
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^miRNAとタンパク質の関わり:Dennis Murphy, Barry Dancis and James R Brown, The evolution of core proteins involved in microRNA biogenesis, BMC Evolutionary Biology 2008.
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^miRBase (the microRNA database, ミアベース) に登録されているmiRNA塩基配列の総数:Sam Griffiths-Jones, Russell J. Grocock, Stijn van Dongen, Alex Bateman, and Anton J. Enright. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1; 34(Database issue): D140–D144.
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^マイクロRNAの生成機構の総説:Leigh-Ann MacFarlane and Paul R. Murphy、MicroRNA: Biogenesis, Function and Role in Cancer、Curr Genomics. 2010 Nov; 11(7): 537–561。
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^miRNAとsiRNAの翻訳制御:Marco Antonio Valencia-Sanchez, Jidong Liu, Gregory J. Hannon, and Roy Parker、Control of translation and mRNA degradation by miRNAs and siRNAs、Genes & Dev. 2006. 20: 515-524。
^miRNAとsiRNAの機構とその機能:Richard W. Carthew1, Erik J. Sontheimer、Origins and Mechanisms of miRNAs and siRNAs、Cell, Volume 136, Issue 4, 20 February 2009, Pages 642–655.
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^miRNAの治療にも用いられるツール:Eva van Rooij, & Sakari Kauppinen. Development of microRNA therapeutics is
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^miR-34と前立腺がん:Cheng CY, Hwang CI, Corney DC, Flesken-Nikitin A, Jiang L, Oner GM, Munroe RJ, Schimenti JC, Hermeking H, Nikitin AY. miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Rep. 2014 Mar 27;6(6):1000-7.
^miR-34と肺がん:Shi Y, Liu C, Liu X, Tang DG, Wang J. The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells. PLoS One. 2014 Mar 4;9(3):e90022.
^miR-34と大腸がん:Gao J, Li N, Dong Y, Li S, Xu L, Li X, Li Y, Li Z, Ng SS, Sung JJ, Shen L, Yu J. miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene. 2015 Jul 30;34(31):4142-52.
^miR-34と肝臓がん:Gougelet A, Sartor C, Bachelot L, Godard C, Marchiol C, Renault G, Tores F, Nitschke P, Cavard C, Terris B, Perret C, Colnot S. Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations. Gut. 2015 Mar 19. pii: gutjnl-2014-308969.
^miRNAの発現量異常と細胞のがん化について: Pedro P. Medina, Mona Nolde & Frank J. Slack Nature 467, 86–90 (2010) "OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma。
^マイクロRNAをターゲットとした、がん治療:Ramiro Garzon , Guido Marcucci & Carlo M. Croce、Targeting microRNAs in cancer: rationale, strategies and challenges、Nature Reviews Drug Discovery 9, 775–789 (1 October 2010)。
^最初のmicroRNA標的として発見されたmiR-122 (microRNA-122) の薬理的影響についての総説:Morten Lindow and Sakari Kauppinen, Discovering the first microRNA-targeted drug, J. Cell Biol. (2012) Vol. 199 No. 3 407–412.
^慢性C型肝炎ウイルス(HCV)治療薬のmiR-122 Inhibitor (Miravirsen) はフェーズII試験を終えて、高い有効性を示す:Harry L.A. Janssen, M.D., Ph.D., Hendrik W. Reesink, M.D., Ph.D., Eric J. Lawitz, M.D.,
Stefan Zeuzem, M.D., Maribel Rodriguez-Torres, M.D., Keyur Patel, M.D., Adriaan J. van der Meer, M.D., Amy K. Patick, Ph.D., Alice Chen, B.A., Yi Zhou, Ph.D., Robert Persson, Ph.D., Barney D. King, M.D., Sakari Kauppinen, Ph.D., Arthur A. Levin, Ph.D., and Michael R. Hodges, M.D. Treatment of HCV Infection by Targeting
MicroRNA. N Engl J Med 2013; 368:1685-1694May 2, 2013.
^Miravirsenは、月1回の投与でHCV治療に効果を示す。Miravirsenは最初のmicroRNA標的薬。:R. Persson, M. R. Hodges, B. D. King, A. Chen, K. Zeh and A. A. Levin. Pharmacokinetics of Miravirsen, a miR-122 Inhibitor, Predict the Prolonged Viral
Load Reduction in Treatment Naive Genotype 1 HCV-Infected Patients. EASL - The International Liver Congress 2015 50th annual Meeting of the European association for the Study of the Liver Vienna, austria april 22-26.
^miRNAを利用した治療研究:Kaladhar B Reddy、MicroRNA (miRNA) in cancer、Cancer Cell International 2015。
^びまん性大細胞型B細胞性リンパ腫を発症した患者の血清中からonco miRNAを検出した:Charles H. Lawrie, Shira Gal, Heather M. Dunlop, Beena Pushkaran, Amanda P. Liggins, Karen Pulford, Alison H. Banham, Francesco Pezzella, Jacqueline Boultwood, James S. Wainscoat, Christian S. R. Hatton and Adrian L. Harris. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. (2008) May;141(5):672-5.
^血液中を安定に巡回するonco RNA (miR-141) の腫瘍マーカーとしての可能性:Patrick S. Mitchell, Rachael K. Parkin, Evan M. Kroh, Brian R. Fritz, Stacia K. Wyman, Era L. Pogosova-Agadjanyan, Amelia Peterson, Jennifer Noteboom, Kathy C. O'Briant, April Allen, Daniel W. Lin, Nicole Urban, Charles W. Drescher, Beatrice S. Knudsen, Derek L. Stirewalt, Robert Gentleman, Robert L. Vessella, Peter S. Nelson, Daniel B. Martin and Muneesh Tewari. Circulating microRNAs as stable blood-based markers for cancer detection. PNAS July 29, (2008) vol. 105 no. 30 10513–10518.
^エクソソーム中でマイクロRNAは安定に存在している:Johan Skog, Tom Würdinger, Sjoerd van Rijn, Dimphna H. Meijer, Laura Gainche, William T. Curry, Jr, Bob S. Carter, Anna M. Krichevsky & Xandra O. Breakefield. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nature Cell Biology 10, 1470 - 1476 (2008).
^マイクロRNA臨床研究のレビュー:Josie Hayes, Pier Paolo Peruzze, and Sean Lawler、MicroRNAs in cancer: biomarkers, functions and therapy、Trends in Molecular Medicine, August 2014, Vol. 20, No. 8。