Dibekasin

Dibekasin
Data klinis
Nama dagangPanimycin, Tokocin
AHFS/Drugs.comInternational Drug Names
Kode ATC
Pengenal
  • (2S,3R,4S,5S,6R)-4-Amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminometil)oksan-2-il]oksi-2-hidroksisikloheksil]oksi-6-(hidroksimetil)oksana-3,5-diol
Nomor CAS
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Ligan PDB
CompTox Dashboard (EPA)
ECHA InfoCard100.047.316 Sunting di Wikidata
Data sifat kimia dan fisik
RumusC18H37N5O8
Massa molar451,52 g·mol−1
Model 3D (JSmol)
  • C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N)N)N
  • InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
  • Key:JJCQSGDBDPYCEO-XVZSLQNASA-N

Dibekasin (3',4'-dideoksikanamisin B) adalah salah satu antibiotik aminoglikosida. Obat ini adalah turunan semisintetik dari kanamisin yang dikembangkan oleh Hamao Umezawa dan kolaborator Meiji Seika.[1][2] Obat ini telah digunakan dalam kombinasi dengan sulbenisilin.[3]

Referensi

  1. ^ Umezawa H, Umezawa S, Tsuchiya T, Okazaki Y (July 1971). "3',4'-Dideoxy-Kanamycin B Active Against Kanamycin-Resistant Escherichia coli and Pseudomonas aeruginosa". The Journal of Antibiotics. 24 (7): 485–487. doi:10.7164/antibiotics.24.485. PMID 4998037.
  2. ^ Umezawa H (November 1982). "Découverte de la dibékacine et de ses aspects chimiques [Discovery of dibekacin and its chemical aspects]". La Nouvelle Presse Médicale. 11 (46): 3379–84. PMID 7155844.
  3. ^ Aonuma S, Ariji F, Oizumi K, Konno K (June 1987). "Electron microscopy of Pseudomonas aeruginosa treated with sulbenicillin and dibekacin". Tohoku J. Exp. Med. 152 (2): 119–28. doi:10.1620/tjem.152.119. PMID 3114912.


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