Lumefantrin

Lumefantrin
Data klinis
AHFS/Drugs.comInternational Drug Names
MedlinePlusa609024
Rute
pemberian		Oral
Kode ATC
Status hukum
Status hukum
  • US: C
Pengenal
  • 2-(Dibutilamino)-1-[(9Z)-2,7-dikloro-9-(4-klorobenzilidena)-9H-fluoren-4-il]etanol
Nomor CAS
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.133.797 Sunting di Wikidata
Data sifat kimia dan fisik
RumusC30H32Cl3NO
Massa molar528,94 g·mol−1
Model 3D (JSmol)
Titik leleh130 hingga 132 °C (266 hingga 270 °F)
  • Clc1ccc(cc1)\C=C3\c4c(c2c(cc(Cl)cc23)C(O)CN(CCCC)CCCC)ccc(Cl)c4
  • InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- checkY
  • Key:DYLGFOYVTXJFJP-MYYYXRDXSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Lumefantrin atau benflumetol adalah obat antimalaria. Obat ini hanya digunakan dalam kombinasi dengan artemeter. Istilah "ko-artemeter" terkadang digunakan untuk menggambarkan kombinasi ini.[1] Lumefantrin memiliki waktu paruh yang jauh lebih panjang dibandingkan dengan artemeter, dan oleh karena itu dianggap dapat membersihkan parasit sisa yang tersisa setelah pengobatan kombinasi.[2]

Lumefantrin bersama dengan pironaridin dan naftokuin, disintesis selama upaya penelitian obat antimalaria Proyek 523 Cina yang dimulai pada tahun 1967; semua senyawa ini digunakan dalam terapi antimalaria kombinasi.[3][4][5]

Referensi

  1. ^ Toovey S, Jamieson A, Nettleton G (August 2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease. 1 (3): 177–179. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.
  2. ^ White NJ, van Vugt M, Ezzet F (August 1999). "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. PMID 10496300. S2CID 72714420.
  3. ^ Cui L, Su XZ (October 2009). "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-Infective Therapy. 7 (8): 999–1013. doi:10.1586/eri.09.68. PMC 2778258. PMID 19803708.
  4. ^ Benjamin J, Moore B, Lee ST, Senn M, Griffin S, Lautu D, et al. (May 2012). "Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study". Antimicrobial Agents and Chemotherapy. 56 (5): 2465–2471. doi:10.1128/AAC.06248-11. PMC 3346652. PMID 22330921.
  5. ^ Laman M, Moore BR, Benjamin JM, Yadi G, Bona C, Warrel J, et al. (December 2014). "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLOS Medicine. 11 (12): e1001773. doi:10.1371/journal.pmed.1001773. PMC 4280121. PMID 25549086.

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