Arantxa Sánchez Vicario defeated Monica Seles in the final, 7–6(7–5), 0–6, 6–2, to win the women's singles tennis title at the 1998 French Open. It was Sánchez Vicario's third French Open title and fourth major singles title overall, and the last major singles final for both her and Seles. This was also the third and the last victory for Sánchez Vicario over Seles in their rivalry.
This event is the most recent edition of the French Open to have a final that was a rematch of a previous years' final. Both finalists previously met in 1991, which was won by Seles.