Simona Halep was the defending champion, but lost to Amanda Anisimova in the quarterfinals. Anisimova became the first tennis player born in the 21st century to reach the quarterfinals and semifinals of a major.[4]
For the first time since the 1978 Australian Open, none of the four semifinalists had previously reached a major singles final. Of the four, Johanna Konta was the only one who had previously reached a semifinal. Of Konta's seven appearances in the main draw of the French Open, this is the only edition where she progressed beyond the first round.
This marked the final major main draw appearance of former world No. 4 and 2016 WTA Finals champion Dominika Cibulková; she was defeated by Aryna Sabalenka in the first round. It was also the first French Open main draw appearance of future world No. 1 and four-time champion Iga Świątek, who reached the fourth round and was defeated by Halep. It was also the first major appearance of future Wimbledon champion Elena Rybakina, who entered the main draw as a qualifier and lost to Kateřina Siniaková in the first round.