AP1B1

AP1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HMY, 4P6Z
Identifiers
Aliases	AP1B1, ADTB1, AP105A, BAM22, CLAPB2, adaptor related protein complex 1 beta 1 subunit, adaptor related protein complex 1 subunit beta 1, KIDAR
External IDs	OMIM: 600157; MGI: 1096368; HomoloGene: 21972; GeneCards: AP1B1; OMA:AP1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	29,423,179 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,992,791 bp
RNA expression pattern
	Top expressed in
	middle frontal gyrus; ; paraflocculus of cerebellum; ; Brodmann area 10; ; frontal pole; ; mucosa of transverse colon; ; right adrenal cortex; ; spleen; ; lymph node; ; left adrenal gland; ; mucosa of esophagus;
	Top expressed in
	neural layer of retina; ; fetal liver hematopoietic progenitor cell; ; stroma of bone marrow; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; lip; ; yolk sac; ; cerebellar cortex; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; protein kinase binding; clathrin binding;
Cellular component	trans-Golgi network membrane; membrane; Golgi membrane; lysosomal membrane; clathrin-coated vesicle membrane; membrane coat; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin adaptor complex; Golgi apparatus; cytosol; intracellular membrane-bounded organelle;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; mitigation of host defenses by virus; heart development; determination of left/right symmetry; protein transport; intracellular protein transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	162
	11764
	ENSG00000100280
	ENSMUSG00000009090
	Q10567
	O35643
	NM_145730; NM_001127; NM_001166019
	NM_001243043; NM_001243044; NM_007454; NM_001355659; NM_001355660
NP_001118; NP_001159491; NP_663782; NP_001365491; NP_001365492;
	NP_001365493; NP_001365494; NP_001365495
	NP_001229972; NP_001229973; NP_031480; NP_001342588; NP_001342589
	Wikidata
View/Edit Human	View/Edit Mouse

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.^[5]^[6]^[7]

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.^[7]