AP1G1

AP1G1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IU1
Identifiers
Aliases	AP1G1, ADTG, CLAPG1, adaptor related protein complex 1 gamma 1 subunit, adaptor related protein complex 1 subunit gamma 1, USRISD
External IDs	OMIM: 603533; MGI: 101919; HomoloGene: 47995; GeneCards: AP1G1; OMA:AP1G1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	71,809,201 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	110,590,836 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; epithelium of colon; ; sperm; ; corpus epididymis; ; islet of Langerhans; ; sural nerve; ; left testis; ; middle temporal gyrus; ; right testis;
	Top expressed in
	genital tubercle; ; tail of embryo; ; cumulus cell; ; granulocyte; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; Paneth cell; ; ventricular zone; ; spermatocyte; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; GTP-dependent protein binding; protein binding; kinesin binding;
Cellular component	recycling endosome; clathrin-coated endocytic vesicle membrane; Golgi apparatus; trans-Golgi network membrane; membrane; intracellular membrane-bounded organelle; Golgi membrane; lysosomal membrane; AP-type membrane coat adaptor complex; clathrin-coated vesicle membrane; membrane coat; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin-coated vesicle; clathrin adaptor complex; cytoplasm; cytosol; AP-1 adaptor complex;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; mitigation of host defenses by virus; Golgi to lysosome transport; positive regulation of natural killer cell degranulation; melanosome organization; endosome to melanosome transport; protein transport; intracellular protein transport; positive regulation of natural killer cell mediated cytotoxicity; vesicle-mediated transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	164
	11765
	ENSG00000166747
	ENSMUSG00000031731
	O43747
	P22892
	NM_001128; NM_001030007
	NM_001301211; NM_009677
	NP_001025178; NP_001119
	NP_001288140; NP_033807
	Wikidata
View/Edit Human	View/Edit Mouse

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.^[5]^[6]

Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

AP1G1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031731 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
^ ^a ^b ^c Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
^ "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit".
^ ^a ^b ^c Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/s0092-8674(00)81650-5. PMID 10535737. S2CID 15288582.
^ ^a ^b ^c Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
^ ^a ^b Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
^ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
^ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". The Journal of Biological Chemistry. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
^ Horikawa HP, Kneussel M, El Far O, Betz H (Nov 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Molecular and Cellular Neurosciences. 21 (3): 454–62. doi:10.1006/mcne.2002.1191. PMID 12498786. S2CID 54366866.