BPS domain

BPS
crystal structure of the grb14 bps region in complex with the insulin receptor tyrosine kinase
Identifiers
SymbolBPS
PfamPF08947
InterProIPR015042
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/|Grb10/Grb14. It mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor. It is composed of two beta strands and a C-terminal helix.[1]

References

  1. ^ Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR (October 2005). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325–33. doi:10.1016/j.molcel.2005.09.001. PMC 4526137. PMID 16246733.
This article incorporates text from the public domain Pfam and InterPro: IPR015042


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