Trional

Trional
Clinical data
ATC code	none;
Legal status
Legal status	US: Schedule III;
Identifiers
	IUPAC name 2,2-bis(ethylsulfonyl)butane;
CAS Number	76-20-0 ;
PubChem CID	6433;
ChemSpider	6193 ;
UNII	217727W28W;
CompTox Dashboard (EPA)	DTXSID7046411 ;
ECHA InfoCard	100.000.858
Chemical and physical data
Formula	C8H18O4S2
Molar mass	242.35 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C)(S(=O)(=O)CC)S(=O)(=O)CC;
	InChI InChI=1S/C8H18O4S2/c1-5-8(4,13(9,10)6-2)14(11,12)7-3/h5-7H2,1-4H3 ; Key:LKACJLUUJRMGFK-UHFFFAOYSA-N ;
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Trional (Methylsulfonal) is a sedative-hypnotic^[1] and anesthetic drug with GABAergic actions^{[citation needed]}. It has similar effects to sulfonal, except it is faster acting.^[2]

History

Trional was prepared and introduced by Eugen Baumann and Alfred Kast in 1888.^[3]

Appeared in Agatha Christie's Murder on the Orient Express, And Then There Were None, and other novels such as John Bude's The Lake District Murder as a sleep-inducing sedative; and in In Search of Lost Time (Sodom and Gomorrah) by Marcel Proust as a hypnotic. Sax Rohmer also references trional in his novel Dope.

^ "Trional". Merck's 1907 Index. New York: Merck & Co. 1907. p. 448.
^ Sajous CE (1896). "General Therapeutics". Annual of the Universal Medical Sciences. 5. Philadelphia: F. A. Davis: A-156.
^ Drinkwater H (1924). Fifty years of medical progress, 1873-1922. New York: The Macmillan Company. p. 40.