CDC37

Cell division cycle 37 homolog znany też jako CDC37, to ludzki gen kodujący białko CDC37, zbliżone budową do białka Cdc37 regulującego cykl komórkowy Saccharomyces cerevisiae. Białko CDC37 należy do białek chaperonowych (opiekuńczych)[1]. Wykazano, że CDC37 tworzy kompleks z Hsp90 i wieloma kinazami białkowymi, takimi jak CDK4[2][3], CDK6, SRC, RAF1, MOK, LKB1[4] czy eIF-2[5]. Przypuszczalnie odgrywa kluczową rolę, rekrutując białka kinazowe do Hsp90[1].

Przypisy

  1. ↑ a b Kimura Y., Rutherford SL., Miyata Y., Yahara I., Freeman BC., Yue L., Morimoto RI., Lindquist S. Cdc37 is a molecular chaperone with specific functions in signal transduction. „Genes Dev”. 11. 14, s. 1775-85, 1997. PMID: 9242486. 
  2. ↑ Stepanova L., Leng X., Parker SB., Harper JW. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.. „Genes Dev”. Jun 15;10. 12, s. 1491-502, 1996. PMID: 8666233. 
  3. ↑ Dai K., Kobayashi R., Beach D. Physical interaction of mammalian CDC37 with CDK4.. „J Biol Chem”. Sep 6;271. 36, s. 22030-4, 1996. PMID: 8703009. 
  4. ↑ Boudeau J., Deak M., Lawlor MA., Morrice NA., Alessi DR. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. „Biochem J”. 370. Pt 3, s. 849-57, 2003. DOI: 10.1042/BJ20021813. PMID: 12489981. 
  5. ↑ Shao J., Grammatikakis N., Scroggins BT., Uma S., Huang W., Chen JJ., Hartson SD., Matts RL. Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. „J Biol Chem”. 276. 1, s. 206-14, 2001. DOI: 10.1074/jbc.M007583200. PMID: 11036079. 

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