Syntetaza glutationowa

Struktura syntetazy glutationowej drożdży (PDB: 1M0W)

Syntetaza glutationowa, GHS (EC 6.3.2.3) – drugi enzym w ścieżce biosyntezy glutationu. Katalizuje połączenie γ-glutamylocysteiny z glicyną tworząc ostatecznie glutation[1]. Ligaza ta jest silnym przeciwutleniaczem. Homologii enzymu występują pospolicie w wielu organizmach, w tym u bakterii, drożdży, ssaków i roślin[2].

Przypisy

  1. ↑ Runa Njålsson, Svante Norgren, Physiological and pathological aspects of GSH metabolism, „Acta Paediatrica”, 94 (2), 2005, s. 132–137, PMID: 15981742.
  2. ↑ Hong Li, Huimin Xu, David E. Graham, Robert H. White, Glutathione synthetase homologs encode α-l-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses, „Proceedings of the National Academy of Sciences of the United States of America”, 100 (17), 2003, s. 9785–9790, DOI: 10.1073/pnas.1733391100, PMID: 12909715, PMCID: PMC187843.

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