Latrophilin 2

ADGRL2
Identifiers
Aliases	ADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
External IDs	OMIM: 607018; MGI: 2139714; HomoloGene: 22712; GeneCards: ADGRL2; OMA:ADGRL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	81,993,932 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	148,990,555 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; ventricular zone; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; left ovary; ; gastric mucosa; ; lower lobe of lung; ; ganglionic eminence; ; right ovary;
	Top expressed in
	hand; ; maxillary prominence; ; left lung lobe; ; human fetus; ; mandibular prominence; ; renal corpuscle; ; skin of back; ; stria vascularis; ; belly cord; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; latrotoxin receptor activity; signal transducer activity; carbohydrate binding;
Cellular component	integral component of membrane; membrane; intracellular anatomical structure; integral component of plasma membrane; neuron projection;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; brain development;
	Sources:Amigo / QuickGO
Orthologs
	23266
	99633
	ENSG00000117114
	ENSMUSG00000028184
	O95490
	Q8JZZ7
NM_001297704; NM_001297705; NM_001297706; NM_012302; NM_001330645;
	NM_001350698; NM_001350699; NM_001366002; NM_001366003; NM_001366004; NM_001366005; NM_001366006; NM_001366007; NM_001366008; NM_001366009; NM_001393349; NM_001393350; NM_001393351; NM_001393352; NM_001393353; NM_001393354
	NM_001081298
NP_001284633; NP_001284634; NP_001284635; NP_001317574; NP_036434;
	NP_001337627; NP_001337628; NP_001352931; NP_001352932; NP_001352933; NP_001352934; NP_001352935; NP_001352936; NP_001352937; NP_001352938
NP_001074767; NP_001392915; NP_001392916; NP_001392917; NP_001392918;
	NP_001392919; NP_001392920; NP_001392921; NP_001392922; NP_001392923; NP_001392924; NP_001392925; NP_001392926; NP_001392927; NP_001392928; NP_001392929; NP_001392930; NP_001392931; NP_001392932; NP_001392933; NP_001392934; NP_001392935; NP_001392936; NP_001392937; NP_001392938; NP_001392939; NP_001392940; NP_001392947; NP_001392948
	Wikidata
View/Edit Human	View/Edit Mouse

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.^[5]^[6]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117114 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
^ ^a ^b "Entrez Gene: LPHN2 latrophilin 2".