Protein FLICE-i

Protein FLICE-i (bahasa Inggris: FLICE-inhibitory protein, CASP8 and FADD-like apoptosis regulator, FADD-like IL-1beta-converting enzyme inhibitory protein, FLIP) adalah faktor transkripsi dengan berkas genetik CFLAR pada kromosom 2 lokasi 2q33-q34,[1] yang banyak terdapat pada jaringan otot dan jaringan limfoid,[2] sebagai regulator apoptosis.

Overekspresi FLIP dapat melindungi sel tumor dari mekanisme apoptosis.[3]

Rujukan

  1. ^ (Inggris) "CFLAR CASP8 and FADD-like apoptosis regulator [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-10-26.
  2. ^ (Inggris) "Inhibition of death receptor signals by cellular FLIP". Institute of Biochemistry, Lausanne branch, University of Lausanne; Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schröter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J. Diakses tanggal 2010-10-26.
  3. ^ (Inggris) "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer". Cancer Research UK Institute for Cancer Studies, Division of Cancer Studies, Department of Pathology, The Medical School, University of Birmingham; Dutton A, Young LS, Murray PG. Diakses tanggal 2010-10-26.
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