CLTC
Protein-coding gene in the species Homo sapiens
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene .[ 5] [ 6]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[ 7]
Interactions
CLTC has been shown to interact with PICALM [ 8] and HGS .[ 9]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141367 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047126 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics . 11 (1): 174–8. doi :10.1016/0888-7543(91)90115-U . PMID 1765375 .
^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35. doi :10.1093/dnares/1.1.27 . PMID 7584026 .
^ "Entrez Gene: CLTC clathrin, heavy chain (Hc)" .
^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" . Mol. Biol. Cell . 10 (8): 2687–702. doi :10.1091/mbc.10.8.2687 . ISSN 1059-1524 . PMC 25500 . PMID 10436022 .
^ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes" . EMBO J . 20 (17): 5008–21. doi :10.1093/emboj/20.17.5008 . ISSN 0261-4189 . PMC 125612 . PMID 11532964 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
Further reading
Murphy JE, Keen JH (1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia" . J. Biol. Chem . 267 (15): 10850–5. doi :10.1016/S0021-9258(19)50096-5 . PMID 1587861 .
Corvera S (1990). "Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes" . J. Biol. Chem . 265 (5): 2413–6. doi :10.1016/S0021-9258(19)39811-4 . PMID 2154445 .
Scarmato P, Kirchhausen T (1990). "Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3" . J. Biol. Chem . 265 (7): 3661–8. doi :10.1016/S0021-9258(19)39644-9 . PMID 2406259 .
Hanspal M, Luna E, Branton D (1984). "The association of clathrin fragments with coated vesicle membranes" . J. Biol. Chem . 259 (17): 11075–82. doi :10.1016/S0021-9258(18)90624-1 . PMID 6147350 .
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)" . DNA Res . 1 (1): 47–56. doi :10.1093/dnares/1.1.47 . PMID 7584028 .
Fausser JL, Ungewickell E, Ruch JV, Lesot H (1994). "Interaction of vinculin with the clathrin heavy chain". J. Biochem . 114 (4): 498–503. doi :10.1093/oxfordjournals.jbchem.a124206 . PMID 8276759 .
Kedra D, Peyrard M, Fransson I, et al. (1997). "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11" . Hum. Mol. Genet . 5 (5): 625–31. doi :10.1093/hmg/5.5.625 . PMID 8733129 .
Goodman OB, Krupnick JG, Gurevich VV, et al. (1997). "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain" . J. Biol. Chem . 272 (23): 15017–22. doi :10.1074/jbc.272.23.15017 . PMID 9169477 .
Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform" . J. Biol. Chem . 272 (26): 16700–6. doi :10.1074/jbc.272.26.16700 . PMID 9195986 .
McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Lett . 413 (2): 319–22. doi :10.1016/S0014-5793(97)00928-9 . PMID 9280305 . S2CID 42520828 .
Foti M, Mangasarian A, Piguet V, et al. (1998). "Nef-mediated clathrin-coated pit formation" . J. Cell Biol . 139 (1): 37–47. doi :10.1083/jcb.139.1.37 . PMC 2139808 . PMID 9314527 .
Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". Science . 280 (5362): 431–4. Bibcode :1998Sci...280..431D . doi :10.1126/science.280.5362.431 . PMID 9545220 .
Ramjaun AR, McPherson PS (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites" . J. Neurochem . 70 (6): 2369–76. doi :10.1046/j.1471-4159.1998.70062369.x . PMID 9603201 . S2CID 21910795 .
ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker" . Cell . 95 (4): 563–73. doi :10.1016/S0092-8674(00)81623-2 . PMC 4428171 . PMID 9827808 .
Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis" . Proc. Natl. Acad. Sci. U.S.A . 96 (7): 3712–7. Bibcode :1999PNAS...96.3712L . doi :10.1073/pnas.96.7.3712 . PMC 22359 . PMID 10097102 .
Turner CE, Brown MC, Perrotta JA, et al. (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling" . J. Cell Biol . 145 (4): 851–63. doi :10.1083/jcb.145.4.851 . PMC 2133183 . PMID 10330411 .
Hussain NK, Yamabhai M, Ramjaun AR, et al. (1999). "Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells" . J. Biol. Chem . 274 (22): 15671–7. doi :10.1074/jbc.274.22.15671 . PMID 10336464 .
Ybe JA, Brodsky FM, Hofmann K, et al. (1999). "Clathrin self-assembly is mediated by a tandemly repeated superhelix". Nature . 399 (6734): 371–5. Bibcode :1999Natur.399..371Y . doi :10.1038/20708 . PMID 10360576 . S2CID 4406014 .
External links
PDB gallery
1b89 : CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)
1bpo : CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER
1c9i : PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1c9l : PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1utc : CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT