SYT3

SYT3
Identifiers
Aliases	SYT3, SytIII, synaptotagmin 3
External IDs	OMIM: 600327; MGI: 99665; HomoloGene: 9617; GeneCards: SYT3; OMA:SYT3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,639,881 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,049,611 bp
RNA expression pattern
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; right hemisphere of cerebellum; ; prefrontal cortex; ; Brodmann area 9; ; right frontal lobe; ; anterior cingulate cortex; ; hippocampus proper; ; gonad; ; hypothalamus;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; perirhinal cortex; ; cerebellar cortex; ; neural layer of retina; ; Ileal epithelium; ; entorhinal cortex; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	clathrin binding; calcium ion binding; metal ion binding; calcium-dependent phospholipid binding; syntaxin binding; SNARE binding; phosphatidylserine binding;
Cellular component	integral component of membrane; endosome; transport vesicle membrane; membrane; cytoplasmic vesicle; presynapse; plasma membrane; synapse; exocytic vesicle;
Biological process	positive regulation of dendrite extension; cell differentiation; calcium-ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	84258
	20981
	ENSG00000213023
	ENSMUSG00000030731
	Q9BQG1
	O35681
	NM_001160328; NM_001160329; NM_032298
	NM_001114116; NM_016663
NP_001153800; NP_001153801; NP_115674; NP_001153800.1; NP_001153801.1;
	NP_115674.1
	NP_001107588; NP_057872
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213023 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030731 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19" (PDF). Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.
^ "Entrez Gene: SYT3 synaptotagmin III".

Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
Fukuda M, Kanno E, Mikoshiba K (October 1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". The Journal of Biological Chemistry. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry. 275 (9): 6328–36. doi:10.1074/jbc.275.9.6328. PMID 10692432.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
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Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.