COPE (gene)

COPE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A1V, 5A1Y
Identifiers
Aliases	COPE, epsilon-COP, coatomer protein complex subunit epsilon, COPI coat complex subunit epsilon
External IDs	OMIM: 606942; MGI: 1891702; HomoloGene: 5254; GeneCards: COPE; OMA:COPE - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,919,387 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,765,643 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; anterior pituitary; ; granulocyte; ; mucosa of transverse colon; ; C1 segment; ; left adrenal gland; ; right adrenal gland; ; left adrenal cortex; ; right lobe of thyroid gland;
	Top expressed in
	seminal vesicula; ; saccule; ; islet of Langerhans; ; calvaria; ; salivary gland; ; right kidney; ; otic vesicle; ; duodenum; ; yolk sac; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; Golgi membrane; COPI-coated vesicle membrane; transport vesicle; nucleoplasm; COPI vesicle coat; cytoplasmic vesicle; endoplasmic reticulum membrane;
Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; endoplasmic reticulum to Golgi vesicle-mediated transport; protein transport; intra-Golgi vesicle-mediated transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	11316
	59042
	ENSG00000105669
	ENSMUSG00000055681
	O14579
	O89079
	NM_007263; NM_199442; NM_199444; NM_001330469; NM_025088
	NM_021538
	NP_001317398; NP_009194; NP_955474; NP_955476
	NP_067513
	Wikidata
View/Edit Human	View/Edit Mouse

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.^[5]^[6]

Function

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

COPE (gene) has been shown to interact with COPA.^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105669 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821–4. Bibcode:1999CBio....9..821S. doi:10.1016/S0960-9822(99)80365-0. PMID 10469566. S2CID 16182290.
^ ^a ^b "Entrez Gene: COPE coatomer protein complex, subunit epsilon".
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
^ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.

External links

Human COPE genome location and COPE gene details page in the UCSC Genome Browser.

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Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. Bibcode:1993Natur.364..732O. doi:10.1038/364732a0. PMID 8355790. S2CID 4348442.
Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.
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Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
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