DNM3

DNM3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L43, 5A3F
Identifiers
Aliases	DNM3, Dyna III, dynamin 3
External IDs	OMIM: 611445; MGI: 1341299; HomoloGene: 22906; GeneCards: DNM3; OMA:DNM3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,418,466 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,305,603 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pons; ; Brodmann area 46; ; corpus callosum; ; Pars compacta; ; postcentral gyrus; ; superior vestibular nucleus; ; dorsal motor nucleus of vagus nerve; ; pars reticulata; ; orbitofrontal cortex;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; superior colliculus; ; central gray substance of midbrain; ; inferior colliculus; ; pontine nuclei; ; medial vestibular nucleus; ; substantia nigra; ; dorsal tegmental nucleus; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; nitric-oxide synthase binding; type 1 metabotropic glutamate receptor binding; GTP binding; type 5 metabotropic glutamate receptor binding; protein binding; hydrolase activity; GTPase activity; microtubule binding; identical protein binding; structural constituent of postsynapse;
Cellular component	cytoplasm; Golgi apparatus; postsynaptic density; photoreceptor inner segment; dendritic spine; synapse; axon; dendritic spine head; mitochondrion; perinuclear region of cytoplasm; synaptic cleft; microtubule; extracellular exosome; cytoskeleton; mitochondrial membranes; postsynaptic endocytic zone membrane; plasma membrane; membrane; cytoplasmic vesicle; postsynaptic membrane; apical tubulobulbar complex; basal tubulobulbar complex; presynapse; glutamatergic synapse;
Biological process	endocytosis; positive regulation of filopodium assembly; regulation of dendritic spine morphogenesis; negative regulation of dendritic spine morphogenesis; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; synapse assembly; filopodium assembly; membrane fusion; synaptic vesicle budding from presynaptic endocytic zone membrane; postsynaptic neurotransmitter receptor internalization; receptor internalization; synaptic vesicle endocytosis; regulation of synapse structure or activity; postsynapse organization; positive regulation of synaptic vesicle recycling;
	Sources:Amigo / QuickGO
Orthologs
	26052
	103967
	ENSG00000197959
	ENSMUSG00000040265
	Q9UQ16
	Q8BZ98
NM_001136127; NM_001278252; NM_015569; NM_001350204; NM_001350205;
	NM_001350206
	NM_001038619; NM_172646
NP_001129599; NP_001265181; NP_056384; NP_001337133; NP_001337134;
	NP_001337135
	NP_001033708; NP_766234
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.^[5]^[6] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.^[7] DNM3 is upregulated in Sézary's syndrome.^[8]